The Lasix Medicine History
Lasix is a pharmacological agent causing a specific effect for kidneys and increasing speed of urination by inhibiting electrolyte reabsorption in renal tubules and by discharging appropriate fluid amount. It is necessary to take it for pathologies of cardio-vascular systems as well as for arterial hypertension to reduce a load on the blood bed.
Based in 1973, French pharmaceutical company “Sanofi” is very popular among people and produces the medicine. The company includes some modern factories with the high quality equipment and produces more than one hundred medical substances such as vaccines, modern medicines, and veterinary goods. The main groups of medicines supplied to pharmacological market are: hormonal agents, the medicines for treatment of diseases of cardio-vascular system, respiratory apparatus, musculoskeletal system, urinary system, vaccines, and serums.
What is Lasix?
Lasix regards to the class of diuretic medicines. Diuretics are agent or drug, which reduces the discharging of urine from the organism and decreasing urine content in cavities, vessels and tissues. The mechanism of action of the medicine influents on renal apparatus blocking sodium ions reabsorption. That causes low water absorption, so water passes through renal tubules easily and discharges through urine. At that, kidney filtration processes do not increase.
When water discharging through urine, diuretics decrease general amount of liquid blood in functioning blood vessels, decrease load on the vessel bed, reducing arterial tension. Besides, blood stream to heart through veins and load on myocardium and heart chambers, and lesser circulation decrease causing positive impact on lungs.
Diuretics are also in use to normalize the eye ground tension during complex therapy, to reduce intracranial pressure, to do health of a patient if toxical substances poisoning, and to prevent epileptic seizures. There are the next side effects: disorder of water balance, of electrolyte balance, of phosphor exchange, of uric acid, of lipides, of carbohydrates, endocrine disorders, pathologies of excretory function of liver apparatus, and alimentary tract disorders.
It is necessary to prescribe the medicine correctly with help of a specialist and not to take auto therapy to prevent all these complications. The physician prescribes laboratory research and instrumental methods of examination to choose the necessary medicine regarding all indications and contraindications for maximum prevention of side effects.
Pharmacological Group and Position in General Classification of Pharmaceutical
Lasix is a pharmacologic agent causing a specific effect for kidneys and increasing speed of urination by inhibiting electrolyte reabsorption in renal tubules and by discharging appropriate fluid amount. It is necessary to take it for pathologies of cardio-vascular systems as well as for arterial hypertension to reduce a load on the blood bed.
Components, Pharmacologic Properties and Pharmacokinetic Properties of Lasix
French company "Sanofi" produces the Lasix medicine as pills and ampules with solution. There are fifty or sixty pill in a package. Every ampule contains 2 ml of solution for intravenous administration. There are ten or fifty ampules in the package.
There is prescribing information in every package with the Lasix pills and ampules. Every pill contains of 40 mg of the main Furosemide drug substance; each ampule contains of 20 mg of the main Furosemide drug substance. During alimentary administration to the organism, pills absorb into lower alimentary tube, gets to the blood bed, and to kidney apparatus. In kidney apparatus, Furosemide blocks reabsorption of sodium and chlorine ions and increases water diffusion. With alimentary administration, the bioavailability of medicine is rather high, it is 65%. Metabolites and unaltered medicine excrete through kidneys.
With intravenous administration, bioavailability of medicine is 100%. Medicine causes strong diuretic action as well as natriuresis and choleric effect. With intravenous administration, peripheric vessels are wider, myocardium preload decreases, the filling tension of left heart ventricle decreases, and the main pulmonary artery tension decreases. So, reducing load on the blood bed and reducing general peripheral vascular resistance decreasing arterial tension. The medicine acts in an hour after per os taking. Duration of effect takes up to eight hours. With intravenous injection, effect develops in five minutes and takes two hours.
Lasix indications
Indication for complex therapy:
- Various edema caused by cardio-vascular system and kidney diseases, pregnancy, and intoxication.
- Emergency methods of therapy for edema of brain, spinal cord, intracranial hypertension, and edema of lungs.
- High blood pressure.
- Kidney failure.
Spectrum of the Main Contraindications of Lasix Pills and Solution
Contraindications: allergic reactions for similar medicines in medical history as well as all symptoms of hypersensitivity of organism, acute glomerular nephritis, kidney failure and urine incoming to the bladder, coma caused by severe liver disease, disorder of salt and water balance, disorder of acid-base balance, and especially low level of potassium and sodium.
Side Effects of Lasix
There are the next side effects:
- Hypotension.
- Dry mouth, discomfort in the mouth, dry mucous membrane, and thirst.
- Indigestion disorders, sickness, vomiting, strange stomachache, constipation, and loose stool.
- Pancreas inflammation.
- Hypovolemia, dehydration, reduced levels of potassium, sodium, chlorine, and calcium in the blood caused by this disorder, and high concentration of uric acid in blood.
- Skin and skin appendage inflammation, dysopsia, hearing disorder, creeps, skin tingling, numbness, systemic and unsystemic giddiness, and muscular weakness.
- Retention of the patients suffering from benign prostatic tumor.
- High cholesterol, harmful lipoprotein, and triglyceride levels.
- Reduced glucose tolerance basing on the results of laboratory tests.
- Acute pancreas inflammation.
Using of the Lasix Drug
It is necessary to take the drug per os mornings before meal. Recommended initial per os dose is 20-80 mg; recommended initial intravenous administration dose is 20-40 mg at inpatient department conditions. Taking and intravenous administration ratio is 2-3 times a week.
Precautions
There are many side effects of the medicine. Before the first taking, it is necessary to consult a specialist and not to take auto therapy. Before medical prescription, it is necessary to know about liver and kidney conditions, and to reduce the dose or to stop to take medicine if it is necessary. It is necessary to take the medicine carefully when driving. With side effects, it is necessary to consult a physician about the following using of the drug.
Taking during Pregnancy
There are contraindications of taking of the medicine upon pregnancy and nursing. It is recommended to take other medicines for treatment of pathologic process.
Overdose of the Lasix Drug
If taking big doses or big amount of pills, the symptoms similar to side effects are possible. They are hypotension, the main acid balance and electrolyte level disorder, giddiness, dry mouth, discomfort in the mouth, thirst, hearing disorder, and dysopsia. Hospital treatment is necessary to correct electrolyte disorders and to replace total liquid blood volume in blood vessels. The next measures depend on amount of taken pills and clinical aspects.
Interaction with Other Medicines
Simultaneous taking of the medicine with cardiac glycosides, aminoglycosides, and cephalosporins is forbidden as it may increase their toxicity.
Keeping of the Lasix Drug
For domiciliary, it is necessary to remember general rules:
- The room temperature should be lower than twenty-five grades; keep the medicine off direct sunlight.
- The keeping time of solution is three years; the keeping time of pills is two years.
- Keep the medicine away from children.
